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名称 ((1S, 4R)-4-(2-Amino-6-(((1R, 4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol
英文名称 ((1S, 4R)-4-(2-Amino-6-(((1R, 4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol
中文名称 （（1S，4R）-4-（2-氨基-6-（（1R，4S）-4-（羟甲基）环戊-2-烯-1-基）氨基）-9H-嘌呤-9-基）环戊-2-烯-1-基）甲醇
CAS号 NA

货号 A987661
规格 10mg, 25mg, 50mg, 100mg
储存温度 -20°C Freezer, U17Under Inert Atmosphere
货期 部分现货，详情请询
用途 仅供实验室使用
备注 (1S, 4R)-4-Amino-2-cyclopentene-1-methanol (-)-Dibenzoyl-L-tartaric Acid is an intermediate in synthesizing ent-Abacavir (Abacavir EP Impurity A) (A105015), an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.