Exendin-4 ,141758-74-9
作者:Exendin-4 ,141758-74-9 发布时间:2022-08-01 11:15:17
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Exendin-4
货号 规格 价格
WH0001-1 1mg 1500.00
WH0001-5 5mg 3200.00
WH0001-10 10mg 4700.00
Exendin-4的生物活性
Exendin-4(Exenatide), a 39 amino acid peptide, activates GLP-1 (glucagon-like peptide-1) receptors to increase intracellular cAMP in pancreatic acinar cells and has no effect on VIP receptor.
IC50 Value:
Target: Glucagon Receptor
Exendin-4 stimulates proliferation of HCAECs through PKA-PI3K/Akt-eNOS activation pathways via a GLP-1(glucagon-like peptide-1) receptor-dependent mechanism. Exendin-4, the long-acting GLP-1 receptor agonist, is an incretin mimetic approved for type 2 diabetes mellitus treatment. Studies also demonstrated its neurotrophic/protective activity in cellular and animal models of stroke, Alzheimer's and Parkinson's diseases.
化学信息
分子量:4186.57
分子式:C₁₈₄H₂₈₂N₅₀O₅₀S
CAS号:141758-74-9
溶剂/溶解度:10 mM in DMSO, H2O: ≤ 1.23 mg/mL (Need ultrasonic and warming)
纯度:大于98%
储存温度 -20℃