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名称 货号 英文名、缩写 分子量 规格 价格 DBCO-PEG-MAL PS2-MDB-5K DBCO-PEG-MAL 5000 0.1g、0.5g 现询 DBCO-PEG-MAL PS2-MDB-2K DBCO-PEG-MAL 2000 0.1g、0.5g 现询 DBCO-PEG-MAL PS2-MDB-3K DBCO-PEG-MAL 3400 0.1g、0.5g 现询 DBCO-PEG-MAL PS2-MDB-1K DBCO-PEG-MAL 1000 0.1g、0.5g 现询 DBCO-PEG-MAL PS2-MDB-10K DBCO-PEG-MAL 10000 0.1g、0.5g 现询 （备注：非常规分子量：400、600。精确聚合度的小分子定制。） 结构式： 基本信息： 中文名称：Dibenzocyclooctyne-聚乙二醇-马来酰亚胺 (DBCO-PEG-MAL) 别名：DBCO-PEG-Maleimide 英文名称：DBCO-PEG-Maleimide，DBCO-PEG-MAL CAS：- 分子量：400、600、1K、2K、3.4K、4K、5K、10K 纯度：95%以上 应用简介： MaleimidePEG DBCO (dibenzocycolctyne) is one of DBCO PEG derivatives that can goClick Chemistry reaction without a need of any metal catalysts. Thestrain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, alsotermed as the Cu-free click reaction, is a bioorthogonal reaction that enablesthe conjugation of two molecules in aqueous solution. DBCO PEG derivativespossess fast kinetics and stability in aqueous buffer. DBCO reagents can beused to label azide-modified biomolecules spontaneous without the need fortoxic Cu catalysts. Meanwhile, maleimide group can react with sulfhydryl(Thoil) groups at pH 6.5-7.5 easily. PEGylation can increase solubility andstability and reduce immunogenicity of peptides and proteins. It can alsosuppress the non-specific binding of charged molecules to the modifiedsurfaces. Copper-freeClick Reaction Procedures: Preparethe azide-containing reagents in reaction buffer. AddDBCO reagents to azide containing reagents. Add 1 mol equivalent of limitingreagent to 1.5~3.0 mol equivalents of abundance reagent. Incubatethe reaction at room temperature for 2~4 hours or 2~12 hours at 4℃. Purifyconjugates either by dialysis or size-exclusion chromatograph. 物理性质： 状态：淡黄色到黄色固体，或者半固体，取决于分子量。 溶解性：溶于DMSO,DMF等溶剂。 保持条件：-20℃长期保存，避光，干燥。 注意事项：取用一定要干燥，避免频繁的溶解和冻干。 反应性：DBCO于含有N3基团的反应。MAL可以和SH。 技术指标： 纯度（PEG）：95%以上 取代率（DBCO）：90%以上 取代率（MAL）：90%以上 分散系数（PDI）：小于等于1.05 分析：COA、GPC、NMR、MALDI-TOF